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United Nations employee Gerry Lane traverses the world in a race against time to stop the Zombie pandemic that is toppling armies and governments, and threatening to destroy humanity itself.

The story revolves around United Nations employee Gerry Lane (Pitt), who traverses the world in a race against time to stop a pandemic that is toppling armies and governments and threatening to decimate humanity itself. (C) Paramount

Contacting Thierry, the pilots are diverted and set course for a WHO research facility in Cardiff, Wales. While in the air, a stowaway zombie escapes into the main cabin and attacks the passengers. The plane crashes after Gerry detonates a grenade to blow out all the zombies, the damage causing the pilots to lose control. Believing that Gerry has perished in the crash, Karin, Rachel, Constance, and Tommy are removed from the vessel by the military, as they are no longer considered "essential personnel." Segen and Gerry proceed on foot as the only apparent survivors, although Gerry is critically injured after being impaled by aircraft debris in the crash. He loses consciousness upon arrival at the facility.
Three days later, Gerry awakens inside the main building of the facility and meets with the surviving staff. Gerry reveals a theory he has, based on the fact that the lame soldier, old man and the sickly boy were ignored: the infected do not bite people who are seriously injured or already terminally ill, since they would be unsuitable hosts for viral reproduction. To test the theory someone would need to be infected with a pathogen from the facility. However, the wing of the building in which the pathogens are stored was overrun by zombies after a doctor accidentally infected himself. Gerry decides to go get a pathogen regardless, while Segen and the lead WHO doctor accompany him for backup. They fight their way through the zombies, and although Gerry is separated from Segen and the doctor (who were forced to return to the main building), he reaches the pathogen vault. After getting cornered inside the vault by a lone zombie, Gerry's only course of action is to perform an impromptu test of his theory. He injects himself with an unknown bacterial sample and opens the vault door: the zombie ignores him and later the entire horde runs past him. After he makes it back to the safe main building, everyone rejoices at his theory's success, and they restock their supplies and journey to an extraction point.
Gerry returns to his family (who have adopted Tommy), now relocated off the ship and to a safe zone in Freeport, Nova Scotia. A "vaccine" derived from deadly pathogens is developed that acts as camouflage for the troops battling the infected, and fleeing survivors can now cross zombie-infested areas with ease to quarantine zones. Human offensives begin against the zombies, and hope is restored. Gerry comments, "This isn't the end. Not even close. Our war has just begun."